Guides
Sexual and pelvic health
Libido, vaginal and bladder health, and pelvic floor changes.
Genitourinary syndrome of menopause (GSM): symptoms and treatment
GSM is the vaginal, vulvar, and urinary change caused by falling estrogen. Learn the symptoms, how it is diagnosed, and which treatments work best.Pelvic healthLow sex drive in perimenopause: what is going on and what helps
Why desire often drops in perimenopause, how hormones, sleep, mood, pain, and relationships interact, and which treatments have evidence, including flibanserin.Pelvic healthPainful sex in perimenopause: causes and treatments
Why sex can start to hurt in perimenopause, from vaginal dryness to pelvic floor tension, and the treatments that help, including lubricants, estrogen, and PT.Pelvic healthPelvic floor physical therapy: what it is and who it helps
What happens in pelvic floor physical therapy, which midlife problems it helps, from bladder leaks to painful sex and prolapse, and what the trials show.Pelvic healthRecurrent UTIs after 40: why they happen and how to prevent them
Why bladder infections keep coming back after 40, and the prevention steps with evidence: vaginal estrogen, cranberry, methenamine, more water, and antibiotics.Pelvic healthBladder leaks when you laugh or cough: stress incontinence
Why you leak urine when you laugh, cough, or exercise, how common stress incontinence is at midlife, and what works, from pelvic floor training to surgery.Pelvic healthTestosterone for low libido in women: what the evidence says
What the evidence says about testosterone for low libido in women: who it helps, how much, the safety gaps, and why no US product is FDA-approved for women.Pelvic healthVaginal dryness treatments: from moisturizers to vaginal estrogen
Vaginal dryness treatments compared: lubricants, moisturizers, vaginal estrogen, DHEA, and ospemifene, with what the trials show and where to start.Overview
Falling estrogen changes the tissues of the vagina, vulva and bladder, a condition called genitourinary syndrome of menopause (GSM). It can cause dryness, burning, pain with sex, urinary urgency and repeated bladder infections, and unlike hot flashes it usually gets worse over time without treatment. Desire often shifts too, for reasons that go beyond hormones. These problems are common, rarely discussed and very treatable.
Where to start
For the full picture of what falling estrogen does to these tissues and how it is treated, start with genitourinary syndrome of menopause. If dryness is the main issue, vaginal dryness treatments compares the options from moisturizers to vaginal estrogen. If sex has started to hurt, read painful sex in perimenopause, and if desire is the concern, low sex drive in perimenopause.
Common problems at a glance
| Problem | What it feels like | What has evidence | Read the guide |
|---|---|---|---|
| Vaginal dryness | Dryness, burning or irritation day to day | Moisturizers and lubricants first; low-dose vaginal estrogen for moderate to severe symptoms | Vaginal dryness treatments |
| Painful sex | Pain at the entrance or deeper, often with muscle guarding | Treatment matched to the cause, including vaginal estrogen, DHEA, ospemifene and pelvic floor therapy | Painful sex in perimenopause |
| Low desire | Less interest in sex that bothers you | Fixing pain, sleep, mood and medication issues first; flibanserin; testosterone off-label after menopause | Low sex drive |
| Testosterone questions | Wondering whether low testosterone is the cause | Evidence only for postmenopausal women with diagnosed low-desire disorder; no FDA-approved product for women | Testosterone and libido |
| Recurrent UTIs | Two or more infections in six months, or three in a year | A urine culture each time; vaginal estrogen; cranberry; methenamine | Recurrent UTIs after 40 |
| Bladder leaks | Leaking when you laugh, cough or exercise | Pelvic floor muscle training first; weight loss if overweight; devices or surgery if leaks persist | Stress incontinence |
What the evidence says
Over-the-counter moisturizers, used two or three times a week, and lubricants, used at the time of sex, are first-line for mild symptoms; vaginal moisturizers and lubricants explains how to choose them. Low-dose vaginal estrogen has the strongest evidence for moderate to severe symptoms, and cream, tablet and ring forms work about equally well. Most treatments help within a few weeks, can take 12 weeks for full effect and stop working when you stop.
Pelvic floor physical therapy is the first-line treatment for stress incontinence: in trials, 56% of women who did pelvic floor muscle training reported cure, versus 6% without treatment. Trials also show benefit for prolapse symptoms, and a small trial found less pain with sex. Vaginal laser and radiofrequency treatments are not supported by current evidence, and supplements have not been shown to help dryness.
When to see a clinician
See a clinician if dryness, pain with sex or urinary symptoms are bothering you; an OB-GYN can examine you and rule out infection, skin conditions and other causes. Seek care promptly for a urinary infection with fever, back or side pain, or vomiting, and report any bleeding after menopause. The symptom check can help you raise these topics at the visit, and you can find an OB-GYN near you or browse the directory.
Frequently asked questions
Can perimenopause cause vaginal dryness?
Yes. Vaginal dryness is part of genitourinary syndrome of menopause (GSM), which is driven by falling estrogen and can begin during perimenopause. In SWAN, vaginal dryness was reported by 19.4% of women aged 42 to 53 and by 34.0% of the same group by ages 57 to 69. You do not need to wait for your periods to stop to get treatment.
Why is my sex drive lower in perimenopause?
Hormones are one piece, rarely the whole story. In SWAN, desire declined by late perimenopause even after accounting for age and health, but overall health, psychological well-being and how important sex was to each woman were linked to every aspect of sexual function. Pain with sex, night sweats and poor sleep, depression, medications and relationship strain are common, fixable contributors.
Is vaginal estrogen safe?
For most women, the evidence is reassuring. Low-dose vaginal estrogen acts mainly on vaginal and urinary tissue, and blood estrogen levels generally stay in the postmenopausal range. Large cohort studies found no higher risk of heart disease or cancer, a progestogen is not needed, and in November 2025 the FDA asked manufacturers to remove those risks from its boxed warning.
Why do I keep getting UTIs after 40?
Estrogen supports the lactobacilli that keep the vagina acidic and crowd out bowel bacteria. As estrogen falls, bacteria such as E. coli can colonize the area near the urethra. The American Urological Association recommends vaginal estrogen for perimenopausal and postmenopausal women with recurrent UTIs, along with a urine culture for each episode.
- The NAMS 2020 GSM Position Statement Editorial Panel. The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society. Menopause, 2020
- American Urological Association. Genitourinary Syndrome of Menopause: AUA/SUFU/AUGS Guideline (2025)
- Avis NE, et al. Longitudinal changes in sexual functioning as women transition through menopause: results from the Study of Women's Health Across the Nation. Menopause, 2009
- Dumoulin C, et al. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database of Systematic Reviews, 2018
Coming soon
- Talking to your partner
- Overactive bladder
- Pelvic organ prolapse
- Vulvar skin changes
- Lichen sclerosus
- Sexual health after hysterectomy
- STIs at midlife